Emerging new infections and re-emerging diseases require new vaccines for prevention. It is difficult to decide which new vaccine to develop, especially when making investment decisions in vaccine development. Thus, decision-makers working under constrained resources need tools that can be suitable within their environment and serve as an aid in vaccine prioritization efforts.
In 2012, the IOM released Ranking Vaccines: A Prioritization Framework (Phase I: Demonstration of Concept and a Software Blueprint) which offered a framework and proof of concept for a software prototype called SMART Vaccines to account for various factors influencing vaccine prioritization — demographic, economic, health, scientific, business, programmatic, social, policy factors and public concerns.
In the 2013 report, Ranking Vaccines: A Prioritization Software Tool (Phase II: Prototype of a Decision-Support System) a functional version of SMART Vaccines 1.0 is discussed and elaborated along with its potential application in making decisions about new vaccine development.