Publications from the National Academies of Sciences, Engineering, and Medicine provide objective and straightforward advice to decision makers and the public. This site includes Health and Medicine Division (HMD) publications released after 1998. A complete list of HMD’s publications from its establishment in 1970 to the present is available as a PDF.
International Animal Research Regulations: Impact on ...
Released: May 29, 2012
Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM held a workshop that brought together key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences.
Alzheimer's Diagnostic Guideline Validation: Exploration of ...
Released: February 16, 2012
Scientific advances over the last decade now indicate that Alzheimer’s disease is a continuous, progressive cognitive disease, most likely beginning many years before dementia is apparent. To discuss the next steps in validating new diagnostic guidelines for Alzheimer’s disease, the IOM Forum on Neuroscience and Nervous System Disorders hosted a public workshop session at the Alzheimer’s Association International Conference.
Preventing Violence Against Women and Children - Workshop ...
Released: September 15, 2011
Across the world, violence against women and children poses a high burden on global health. Women and children are particularly susceptible to violence because they often have fewer rights or lack legal protection. Over the last decade, researchers have gathered data on the growing magnitude of this violence, but many research gaps still remain. January 27-28, 2011, the Forum on Global Violence Prevention held its first workshop to explore the prevention of violence against women and children. The workshop opened the discussion on violence-prevention strategies, as well as ways to prevent the spread of violence from one generation to the next.
Glutamate-Related Biomarkers in Drug Development for ...
Released: June 08, 2011
Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer’s, substance abuse, and traumatic brain injury. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The IOM’s Forum on Neuroscience and Nervous System Disorders held a workshop June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers.
Sex Differences and Implications for Translational ...
Released: December 10, 2010
Biological differences between the sexes influence not only individual health but also public health, biomedical research, and health care. The IOM held a workshop March 8-9, 2010, to discuss sex differences and their implications for translational neuroscience research, which bridges the gap between scientific discovery and application.
Future Opportunities to Leverage the Alzheimer's Disease ...
Released: December 10, 2010
Nearly 5.3 million Americans are living with Alzheimer’s disease, and 26.6 million people are affected worldwide. The Alzheimer’s Disease Neuroimaging Initiative (ADNI), a public-private partnership, provides a publicly available, international database of clinical and imaging data to foster research and collaboration on Alzheimer’s research worldwide. The IOM held a workshop on July 12, 2010, to explore opportunities to use information from and partnerships formed because of ADNI to continue to improve the understanding and treatment of Alzheimer’s disease.
The Science of Adolescent Risk-Taking - Workshop Summary ...
Released: December 01, 2010
Adolescence is a time when youth make decisions, both good and bad, that have consequences for the rest of their lives. Some of these decisions put them at risk of lifelong health problems, injury, or death. The IOM held three public workshops between 2008 and 2009 to provide a venue for researchers, health care providers, and community leaders to discuss strategies to improve adolescent health.
Mental, Neurological, and Substance Use Disorders in Sub ...
Released: July 08, 2010
Millions of people in sub-Saharan Africa suffer from mental, neurological, and substance use (MNS) disorders, and most do not have the resources to obtain treatment. The Uganda National Academy of Sciences and the IOM hosted a workshop to discuss the state of care for MNS disorders in sub-Saharan Africa.
CNS Clinical Trials: Suicidality and Data Collection ...
Released: May 04, 2010
The Food and Drug Administration (FDA) now requires that all clinical trials for drugs that affect the central nervous system—including psychiatric drugs—are assessed for whether that drug might cause suicidal ideation or behavior. The IOM’s Forum on Neuroscience and Nervous System Disorders hosted a meeting on June 26, 2009, to discuss the FDA’s new policy and how to analyze best whether suicidal thoughts predict actual suicidal behavior in the near future.
Preliminary Assessment of Readjustment Needs of Veterans ...
Released: March 31, 2010
Nearly 1.9 million U.S. troops have been deployed to Afghanistan and Iraq since October 2001. Many service members and veterans face serious challenges in readjusting to normal life after returning home. This initial report presents findings on the most critical challenges, and lays out the blueprint for the second phase of the study to determine how best to meet the needs of returning troops and their families.