About Publications

Publications from the National Academies of Sciences, Engineering, and Medicine provide objective and straightforward advice to decision makers and the public. This site includes Health and Medicine Division (HMD) publications released after 1998. A complete list of HMD’s publications from its establishment in 1970 to the present is available as a PDF.


  • Biomarker Tests for Molecularly Targeted Therapies: Key to ... Released: March 04, 2016
    Every patient is unique, and the evolving field of precision medicine aims to ensure that the right treatment is delivered to the right patient at the right time. To achieve this, health care providers are increasingly turning to advanced technologies known as biomarker tests for molecularly targeted therapies.
  • Policy and Research Needs to Maximize Independence and ... Released: March 04, 2016
    Living independently and participating in one’s community are priorities for many people. In many regions across the United States, there are programs that support and enable people with disabilities and older adults to live in the setting of their choosing and to participate fully in their communities.
  • Potential Research Priorities to Inform Public Health and ... Released: February 29, 2016
    Given the recent rapid spread of Zika virus (ZIKV) throughout the Americas and the presence of its vector mosquito species within parts of the United States, RADM Nicole Lurie, Assistant Secretary for Preparedness and Response (ASPR), U.S. Department of Health and Human Services (HHS), determined an urgent need for additional research to better characterize ZIKV, especially those issues related to the means of transmission and infection during pregnancy.
  • Mitochondrial Replacement Techniques: Ethical, Social, and ... Released: February 03, 2016
    Mitochondrial replacement techniques (MRT) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. These diseases vary in presentation and severity, but common symptoms include developmental delays, seizures, weakness and fatigue, muscle pain, vision loss, and heart problems, leading to morbidity and in some cases premature death.
  • Global Health Risk Framework: Research and Development of ... Released: January 13, 2016
    Since the 2014 Ebola outbreak, many public- and private-sector leaders have experienced a need for improved management of global public health emergencies. The effects of the Ebola epidemic go well beyond the three hardest-hit countries and beyond the health sector. Education, child protection, commerce, transportation, and human rights have all suffered. The National Academy of Medicine has managed an independent, international commission on improving international management and response to outbreaks. As input to this effort, the Institute of Medicine convened four workshops in the summer of 2015 to inform the commission report. These workshops examined questions of resilient health systems, research and development of medical products, pandemic financing, and governance for global health. Each workshop gathered diverse perspectives on a range of policies, operations, and options for collaboration to improve the global health system.
  • Global Health Risk Framework: Resilient and Sustainable ... Released: January 13, 2016
    Since the 2014 Ebola outbreak, many public- and private-sector leaders have experienced a need for improved management of global public health emergencies. The effects of the Ebola epidemic go well beyond the three hardest-hit countries and beyond the health sector. Education, child protection, commerce, transportation, and human rights have all suffered. The National Academy of Medicine has managed an independent, international commission on improving international management and response to outbreaks. As input to this effort, the Institute of Medicine convened four workshops in the summer of 2015 to inform the commission report. These workshops examined questions of resilient health systems, research and development of medical products, pandemic financing, and governance for global health. Each workshop gathered diverse perspectives on a range of policies, operations, and options for collaboration to improve the global health system.
  • Review of NASA's Evidence Reports on Human Health Risks ... Released: January 07, 2016
    The Institute of Medicine, at the request of the National Aeronautics and Space Administration (NASA) and with guidance from the IOM's Standing Committee on Aerospace Medicine and the Medicine of Extreme Environments, has established the Committee to Review NASA's Evidence Reports on Human Health Risks.
  • Considerations for the Design of a Systemic Review of ... Released: December 29, 2015
    The National Institutes of Health- and many other organizations and individuals worldwide- are interested in the state of the science of preventing Alzheimer's disease, mild cognitive impairment, and age-related cognitive decline.
  • Assessing the Impact of Applications of Digital Health Records ... Released: December 08, 2015
    On July 20, 2015, the IOM’s Forum on Neuroscience and Nervous System Disorders held a public session at the 2015 Alzheimer’s Association International Conference in Washington, DC, to assess the impact of DHRs on Alzheimer’s disease research. “AD is the most common cause of dementia in older adults.” An estimated 46.8 million people worldwide are currently living with dementia, and the prevalence is expected to double every year for the next 20 years. Given the few therapies currently available to treat the symptoms of AD, compared to other central nervous system disorders, this session explored how DHRs may be used to help improve clinical trial design and methodology for AD research.
  • Rapid Medical Countermeasure Response to Infectious ... Released: October 12, 2015
    On March 26 and 27, 2015, the Institute of Medicine (IOM) Forum on Medical and Public Health Preparedness for Catastrophic Events; Forum on Drug Discovery, Development, and Translation; and Forum on Microbial Threats co-convened a workshop in Washington, DC, to discuss how to achieve rapid and nimble MCM capability for new and emerging threats.