Publications from the National Academies of Sciences, Engineering, and Medicine provide objective and straightforward advice to decision makers and the public. This site includes Health and Medicine Division (HMD) publications released after 1998. A complete list of HMD’s publications from its establishment in 1970 to the present is available as a PDF.
Preventing Cognitive Decline and Dementia: A Way Forward ...
Released: June 22, 2017
Individuals, families, and societies around the world are concerned about dementia and the other forms of cognitive impairment that affect many older adults. It is now known that brain changes typically begin years—if not decades—before people show symptoms, which suggests that a window of opportunity exists to prevent, slow, or delay the onset of these conditions. Further, emerging evidence that the incidence and prevalence of dementia are declining in some high-income countries offers hope that public health interventions can be effective in preventing cognitive decline and dementia.
Developing Affordable and Accessible Community-Based ...
Released: May 17, 2017
Accessible and affordable housing can enable community living, maximize independence, and promote health for vulnerable populations. However, the United States faces a shortage of affordable and accessible housing for vulnerable low-income older adults and individuals living with disabilities. This shortage is expected to grow over the coming years given the population shifts leading to greater numbers of older adults and of individuals living with disabilities.
Integrating Clinical Research into Epidemic Response: The ...
Released: April 12, 2017
The 2014 Ebola epidemic in western Africa was the longest and deadliest Ebola outbreak in history, resulting in 28,616 cases and 11,310 deaths. In the midst of the rapidly spreading, highly dangerous contagious disease—with no Ebola-specific vaccines or therapeutics available to help curb the epidemic—the international community implemented clinical trials on investigational agents, not yet studied in humans for safety or efficacy.
Exploring the State of the Science in the Field of Regenerative ...
Released: March 15, 2017
The Forum on Regenerative Medicine hosted its first public workshop with the goal of developing a broad understanding of the opportunities and challenges associated with regenerative medicine cellular therapies and related technologies. Stakeholder groups, including research scientists, clinicians, and representatives from patient groups and industry, presented their perspectives and participated in discussions during the workshop, which focused on an exploration of the state of the science of cell-based regenerative therapies within the larger context of patient care and policy. The workshop rapporteurs have prepared this proceedings as a factual summation of the session discussions.
Therapeutic Development in the Absence of Predictive Animal ...
Released: March 10, 2017
Despite the high prevalence and burden of nervous system disorders, development of new therapeutics lags behind other disease areas. Gaps in understanding the underlying pathophysiology, a dearth of biomarkers, and limitations in the capacity of animal models to predict drug efficacy for human brain disorders have contributed to a high rate of late stage failures in drug development and decreased investment in neuroscience research programs at pharmaceutical companies. On September 12-13, 2016, the National Academies of Sciences, Engineering, and Medicine’s Forum on Neuroscience and Nervous System Disorders hosted a public workshop to explore opportunities to accelerate drug development absent predictive animal models.
Assessment of the Department of Veterans Affairs Airborne ...
Released: February 28, 2017
Concerns over possible adverse effects of wartime exposure to smoke from trash burning in Iraq, Afghanistan, and other locations in Southwest Asia have stimulated both research and Congressional action. Public Law 112-260, § 201 (enacted January 10, 2013) directed the Department of Veterans Affairs (VA) to establish and maintain a registry for service members who may have been exposed to toxic airborne chemicals and fumes generated by open burn pits. VA asked the National Academies to take on the responsibility to fulfill a provision of this law that called for an independent scientific organization to prepare a report addressing issues related to the establishment and conduct of the registry and use of the information it collects.
Countering Violent Extremism Through Public Health Practice ...
Released: February 17, 2017
Countering violent extremism (CVE) consists of various prevention and intervention approaches to increase the resilience of communities and individuals to radicalization toward violent extremism, to provide nonviolent avenues for expressing grievances, and to educate communities about the threat of recruitment and radicalization to violence.
Real-World Evidence Generation and Evaluation of ...
Released: February 15, 2017
The traditional process for evaluating new therapeutics does not produce the evidence that patients, clinicians, and payers need for real-world decisions. The volume and complexity of information about individual patients is greatly increasing with use of electronic records and personal devices. Potential effects on medical product development in the context of this wealth of real-world data are numerous and varied, ranging from the ability to determine both large-scale and patient-specific effects of treatments to assessing how therapeutics affect patients’ lives through measurement of lifestyle changes.
Integration of FDA and NIOSH Processes Used to Evaluate ...
Released: February 01, 2017
The Food and Drug Administration (FDA) and the National Institute for Occupational Safety and Health (NIOSH) have responsibilities for evaluating and regulating respiratory protective devices (RPDs) for health care workers. To provide input to NIOSH and FDA and to discuss potential next steps to integrate the two agencies’ processes to certify and approve N95 respirators for use in health care settings, a workshop was held by the National Academies of Sciences, Engineering, and Medicine (the National Academies).
International Perspectives on Integrating Ethical, Legal, and ...
Released: January 09, 2017
Emerging neurotechnologies—devices and techniques designed to collect information about the brain or affect its function—are becoming increasingly important due to scientific and technological advances and a persistent need to develop effective therapies to address the large global burden of neurological and psychiatric disease. The Organisation for Economic Co-operation and Development (OECD)—in collaboration with Arizona State University and the National Academies of Sciences, Engineering, and Medicine—held a workshop in Washington, DC, on Neurotechnology and Society: Strengthening Responsible Innovation in Brain Science.