Publications from the National Academies of Sciences, Engineering, and Medicine provide objective and straightforward advice to decision makers and the public. This site includes Health and Medicine Division (HMD) publications released after 1998. A complete list of HMD’s publications from its establishment in 1970 to the present is available as a PDF.
Aging and Disability: Beyond Stereotypes to Inclusion ...
Released: March 13, 2018
How do stereotypes affect the health and independence of aging adults and those with disabilities? How do they impact the industries that interact with these populations? And what are some opportunities to disrupt the narrative and change perceptions of what it means to be older or have a disability?
Enabling Novel Treatments for Nervous System Disorders by ...
Released: March 08, 2018
The blood-brain barrier (BBB) presents a special challenge to the development of therapeutics for many central nervous system (CNS) disorders. Far from acting simply as a physical barrier, the BBB is a complex dynamic system involving several cell types, passive and active transport mechanisms, and adaptive function to control the exchange of substances between the blood and the CNS. Few therapeutic agents readily traverse the BBB to reach the brain or spinal cord, including most small molecule drugs and the vast majority of large molecules such as proteins.
Examining the Impact of Real-World Evidence on Medical ...
Released: February 12, 2018
Randomized, controlled clinical trials (RCTs) have traditionally served as the gold standard for evidence generation in support of medical product development and evaluation. However, it is increasingly recognized that RCTs have inherent limitations, particularly with regard to generalizability, and time and monetary investment. Data from sources supplemental to RCTs, such as safety surveillance, observational studies, registries, claims, or patient-centered outcomes research, would be valuable to support biomedical research, including medical product development and evaluation.
Review of NASA's Evidence Reports on Human Health Risks ...
Released: January 10, 2018
The National Academies of Science, Engineering and Medicine, at the request of the National Aeronautics & Space Administration (NASA) and with guidance from the National Academies’ Standing Committee on Aerospace Medicine and the Medicine of Extreme Environments, established a committee to review NASA’s Evidence Reports on Human Health Risks. These evidence reports focus on human health risks for long-duration and exploration spaceflights.
Building a National Capability to Monitor and Assess Medical ...
Released: October 31, 2017
During public health emergencies (PHEs) involving chemical, biological, radiological, or nuclear threats or emerging infectious diseases, medical countermeasures (MCMs)—including drugs, vaccines, and devices—may need to be dispensed or administered to affected populations to help mitigate the human health impact of the threat. As part of the United States’ scientific and research preparedness enterprise, there is an imperative to go “beyond the last mile” of MCM dispensing and administration to build and maintain a national capability to monitor and assess the use of MCMs.
Preparing for a Rapid Response to Major Marine Oil Spills ...
Released: October 27, 2017
Oil spills have potential health and public health consequences both for responders and affected communities; yet neither the current command structure nor the compensation structure account well for responding to these aspects of spills. To explore opportunities to improve preparedness, response, and recovery from oil spills the Gulf Research Program of the National Academies of Sciences, Engineering, and Medicine asked the Health and Medical Division to convene a public workshop titled, Preparing for a Rapid Response to Major Offshore Oil Spills: A Workshop on Research Needs to Protect the Health and Well-Being of Communities.
Navigating the Manufacturing Process and Ensuring the ...
Released: October 26, 2017
Regenerative medicine holds the potential to create living, functional cells and tissues which can be used to repair or replace those that have suffered irreparable damage due to disease, age, traumatic injury, or congenital defects. Although regenerative medicine has the potential to result in health and economic benefits, this relatively new field faces unique manufacturing and regulatory challenges in the development of novel therapies that are both safe and effective. Some of these issues arise because regenerative medicine therapies produce and rely on living cells and tissues, which are inherently variable, even within a single type of cell.
Models and Strategies to Integrate Palliative Care Principles ...
Released: October 24, 2017
The Roundtable on Quality Care for People with Serious Illness hosted a full-day workshop on April 27, 2017 to explore Models and Strategies to Integrate Palliative Care Principles into Care for People with Serious Illness. The workshop aimed to highlight innovative models of community-based care for people of all ages facing serious illness.
Examining Challenges and Possible Strategies to Strengthen ...
Released: October 18, 2017
As the United States continues to adapt to a more digital, mobile, and interconnected world, health care and public health professionals have sought to better prepare for and respond to long-standing and emerging threats to the nation’s health security. Health security is the collective effort to prevent, protect against, mitigate, respond to, and recover from the health consequences of natural, man-made, and technological disasters.
Opportunities for Organ Donor Intervention Research: Saving ...
Released: October 10, 2017
The organ donation and transplantation system strives to honor the gift of donated organs by fully using those organs to save and improve the quality of the lives of their recipients. While most related research to date has focused on improving transplantation processes and health outcomes for recipients, the field of organ donor intervention research looks at ways to enhance the quality and increase the quantity of organs that can be recovered from deceased donors and then successfully transplanted.