About Publications

Publications from the National Academies of Sciences, Engineering, and Medicine provide objective and straightforward advice to decision makers and the public. This site includes Health and Medicine Division (HMD) publications released after 1998. A complete list of HMD’s publications from its establishment in 1970 to the present is available as a PDF.


  • Evaluation of the Department of Veterans Affairs Mental ... Released: January 31, 2018
    Approximately 4 million U.S. veterans supported the wars in Iraq and Afghanistan—Operation Enduring Freedom, Operation Iraqi Freedom, and Operation New Dawn—and many have need for mental health care services. Under a Congressional mandate responding to concerns about the health care experience of these veterans, the Department of Veterans Affairs (VA) asked the National Academies of Sciences, Engineering, and Medicine to assemble a committee of experts to assess veterans’ ability to access mental health services at the VA, as well as the quality of those services.
  • Public Health Consequences of E-Cigarettes : Health and ... Released: January 23, 2018
    Millions of Americans use e-cigarettes, even as rates of smoking combustible tobacco cigarettes continue to decline among youth and adults. In 2016 youth e-cigarette use was substantially higher than cigarette smoking or use of any other tobacco product. The Center for Tobacco Products of the Food and Drug Administration requested that the National Academies of Sciences, Engineering, and Medicine convene a committee of experts to conduct a review the available evidence of the health effects related to the use of e-cigarettes and identify future federally funded research needs.
  • Getting to Zero Alcohol-Impaired Driving Fatalities: A ... Released: January 17, 2018
    Alcohol-impaired driving remains the deadliest and costliest danger on U.S. roads today. Every day in the United States, 29 people die in an alcohol-impaired driving crash—one death every 49 minutes. After decades of progress, alcohol-impaired driving fatality rates plateaued and have increased for the past two years—making it a persistent public health and safety problem.
  • Biomarkers of Neuroinflammation: Proceedings of a Workshop ... Released: September 15, 2017
    Innate and adaptive immunity have become very important areas of investigation for psychiatric, neurologic, and neurodevelopmental disorders, and neurodegeneration resulting from traumatic brain injury. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20–21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of central nervous system diseases.
  • Pain Management and the Opioid Epidemic: Balancing ... Released: July 13, 2017
    Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016.
  • Therapeutic Development in the Absence of Predictive Animal ... Released: March 10, 2017
    Despite the high prevalence and burden of nervous system disorders, development of new therapeutics lags behind other disease areas. Gaps in understanding the underlying pathophysiology, a dearth of biomarkers, and limitations in the capacity of animal models to predict drug efficacy for human brain disorders have contributed to a high rate of late stage failures in drug development and decreased investment in neuroscience research programs at pharmaceutical companies. On September 12-13, 2016, the National Academies of Sciences, Engineering, and Medicine’s Forum on Neuroscience and Nervous System Disorders hosted a public workshop to explore opportunities to accelerate drug development absent predictive animal models.
  • The Health Effects of Cannabis and Cannabinoids: The ... Released: January 12, 2017
    In one of the most comprehensive studies of recent research on the health effects of recreational and therapeutic cannabis use, a new report from the National Academies of Sciences, Engineering, and Medicine offers a rigorous review of relevant scientific research published since 1999. This report summarizes the current state of evidence regarding what is known about the health impacts of cannabis and cannabis-derived products, including effects related to therapeutic uses of cannabis and potential health risks related to certain cancers, diseases, mental health disorders, and injuries. Areas in need of additional research and current barriers to conducting cannabis research are also covered in this comprehensive report.
  • International Perspectives on Integrating Ethical, Legal, and ... Released: January 09, 2017
    Emerging neurotechnologies—devices and techniques designed to collect information about the brain or affect its function—are becoming increasingly important due to scientific and technological advances and a persistent need to develop effective therapies to address the large global burden of neurological and psychiatric disease. The Organisation for Economic Co-operation and Development (OECD)—in collaboration with Arizona State University and the National Academies of Sciences, Engineering, and Medicine—held a workshop in Washington, DC, on Neurotechnology and Society: Strengthening Responsible Innovation in Brain Science.
  • Exploring the Development of a US Department of Labor ... Released: December 30, 2016
    More than 168 million children are affected by child labor worldwide, with a predominance of child labor occurring in sub-Saharan Africa and Asia International Labor Organization estimated in 2012 that 6 million children and more than 15 million adults were victims of forced labor. While strides have been made in understanding the problems of child labor and forced labor, as well as in approaches to reduce the global burden of both issues, additional research could help fill the remaining gaps in knowledge. To these ends, the National Academies of Sciences, Engineering, and Medicine held a workshop, at the request of the U.S. Department of Labor’s (DOL’s) Bureau of International Affairs (ILAB) Office of Child Labor, Forced Labor, and Human Trafficking (OCFT) to illuminate the current gaps in knowledge within the research fields of child labor and forced labor.
  • Developing Multimodal Therapies for Brain Disorders ... Released: November 18, 2016
    Califf was the keynote speaker at a workshop on multimodality therapies for brain disorders, convened by the National Academies of Sciences, Engineering, and Medicine’s Forum on Neuroscience and Nervous Systems Disorders. The workshop brought together key stakeholders to examine the general principles underlying multimodal therapies and to explore challenges, potential barriers, and opportunities for their development from multiple perspectives, including scientific, clinical, regulatory, and financial. These proceedings chronicle the presentations and discussions at the workshop.