Publications from the National Academies of Sciences, Engineering, and Medicine provide objective and straightforward advice to decision makers and the public. This site includes Health and Medicine Division (HMD) publications released after 1998. A complete list of HMD’s publications from its establishment in 1970 to the present is available as a PDF.
Incorporating Weight Management and Physical Activity ...
Released: December 01, 2017
The National Cancer Policy Forum held a public workshop in February 2017 to examine the potential for weight management and physical activity interventions to improve health outcomes for cancer survivors. The workshop, Incorporating Weight Management and Physical Activity throughout the Cancer Care Continuum, highlighted the current evidence base, gaps in knowledge, and research needs on the associations among obesity, physical activity, weight management, and health outcomes for cancer survivors.
Navigating the Manufacturing Process and Ensuring the ...
Released: October 26, 2017
Regenerative medicine holds the potential to create living, functional cells and tissues which can be used to repair or replace those that have suffered irreparable damage due to disease, age, traumatic injury, or congenital defects. Although regenerative medicine has the potential to result in health and economic benefits, this relatively new field faces unique manufacturing and regulatory challenges in the development of novel therapies that are both safe and effective. Some of these issues arise because regenerative medicine therapies produce and rely on living cells and tissues, which are inherently variable, even within a single type of cell.
Examining Challenges and Possible Strategies to Strengthen ...
Released: October 18, 2017
As the United States continues to adapt to a more digital, mobile, and interconnected world, health care and public health professionals have sought to better prepare for and respond to long-standing and emerging threats to the nation’s health security. Health security is the collective effort to prevent, protect against, mitigate, respond to, and recover from the health consequences of natural, man-made, and technological disasters.
Opportunities for Organ Donor Intervention Research: Saving ...
Released: October 10, 2017
The organ donation and transplantation system strives to honor the gift of donated organs by fully using those organs to save and improve the quality of the lives of their recipients. While most related research to date has focused on improving transplantation processes and health outcomes for recipients, the field of organ donor intervention research looks at ways to enhance the quality and increase the quantity of organs that can be recovered from deceased donors and then successfully transplanted.
Biomarkers of Neuroinflammation: Proceedings of a Workshop ...
Released: September 15, 2017
Innate and adaptive immunity have become very important areas of investigation for psychiatric, neurologic, and neurodevelopmental disorders, and neurodegeneration resulting from traumatic brain injury. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20–21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of central nervous system diseases.
Preparing for the Future of Disaster Health Volunteerism ...
Released: August 15, 2017
The Forum on Medical and Public Health Preparedness for Disasters and Emergencies of the Health and Medicine Division of the National Academies of Sciences, Engineering, and Medicine convened a 4-hour session at the 2017 Preparedness Summit. The participants discussed potential characteristics of society in the year 2042 and the key resources, tools, and opportunities necessary to support the development of a robust, scalable, and regularly engaged disaster health volunteer workforce prepared for such a future.
Strengthening the Disaster Resilience of the Academic ...
Released: August 10, 2017
The United States has experienced and continues to face the threat of disasters, and, like all entities, the academic biomedical research community can be affected. The academic biomedical research community is a hub of employment, economic productivity, and scientific progress. Given the crucial contribution and substantial integration of these institutions into the national fabric, the National Academies of Sciences, Engineering, and Medicine convened an expert committee to develop recommendations and guidance to enhance the disaster resilience of the academic biomedical research community.
The Drug Development Paradigm in Oncology: Proceedings ...
Released: July 24, 2017
Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of cancer therapies in the drug development pipeline. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit at an earlier stage of development.
Pain Management and the Opioid Epidemic: Balancing ...
Released: July 13, 2017
Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016.
Enabling Precision Medicine: The Role of Genetics in Clinical ...
Released: July 10, 2017
Those involved in the drug development process face challenges of efficiency and overall sustainability due in part to high research costs, lengthy development timelines, and late-stage drug failures. Novel clinical trial designs that enroll participants based on their genetics represent a potentially disruptive change that could improve patient outcomes, reduce costs associated with drug development, and further realize the goals of precision medicine. On March 8, 2017, the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health hosted the workshop Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development.