About Publications

Publications from the National Academies of Sciences, Engineering, and Medicine provide objective and straightforward advice to decision makers and the public. This site includes Health and Medicine Division (HMD) publications released after 1998. A complete list of HMD’s publications from its establishment in 1970 to the present is available as a PDF.

Reports Index


  • Advancing Gene-Targeted Therapies for Central Nervous System Disorders: Proceedings of a Workshop Released: September 20, 2019
    On April 23 and 24, 2019, the Forum on Neuroscience and Nervous System Disorders convened a workshop titled Advancing Gene-Targeted Therapies for Central Nervous System Disorders in Washington, DC.
  • Transgenic Neuroscience Research: Exploring the Scientific Opportunities Afforded by New Nonhuman Primate Models: Proceedings of a Workshop Released: February 08, 2019
    On October 4, 2018, the Forum on Neuroscience and Nervous System Disorders hosted a 1-day public workshop that brought together experts and key stakeholders from academia, government, industry, and nonprofit organizations to examine the scientific opportunities and challenges, as well as bioethical considerations, of genetically engineered nonhuman primate models for neuroscience research.
  • Harnessing Mobile Devices for Nervous System Disorders: Proceedings of a Workshop Released: November 19, 2018
    To explore current developments and opportunities for using mobile technology to advance research and treatment of central nervous system (CNS) disorders, the National Academies’ Forum on Neuroscience and Nervous System Disorders hosted a workshop on June 5–6, 2018.
  • Neuroforensics: Exploring the Legal Implications of Emerging Neurotechnologies: Proceedings of a Workshop Released: July 06, 2018
    On March 6, 2018, the Forum on Neuroscience and Nervous System Disorders, in collaboration with the Committee on Science, Technology, and Law (CSTL), held a public workshop to explore and advance efforts to identify and evaluate the potential effects of emerging neurotechnologies on the legal system.
  • Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public–Private Partnerships: Proceedings of a Workshop Released: March 23, 2018
    Chronic pain is one of the most prevalent, costly, and disabling health conditions in the United States. In parallel with increasing recognition of the need to treat chronic pain, the opioid epidemic has emerged as a growing public health emergency. In 2017, the National Institutes of Health began exploring public-private partnerships to develop solutions to the opioid crisis and cut in half the time it takes to develop non-addictive analgesics. To help inform this effort, the National Academies’ Forum on Neuroscience and Nervous Systems Disorders hosted a public workshop that brought together experts and stakeholders from academia, federal agencies, advocacy organizations, and companies developing therapeutics for pain and opioid use disorders.
  • Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Blood—Brain Barrier: Proceedings of a Workshop Released: March 08, 2018
    The blood-brain barrier (BBB) presents a special challenge to the development of therapeutics for many central nervous system (CNS) disorders. Far from acting simply as a physical barrier, the BBB is a complex dynamic system involving several cell types, passive and active transport mechanisms, and adaptive function to control the exchange of substances between the blood and the CNS. Few therapeutic agents readily traverse the BBB to reach the brain or spinal cord, including most small molecule drugs and the vast majority of large molecules such as proteins.
  • Biomarkers of Neuroinflammation: Proceedings of a Workshop Released: September 15, 2017
    Innate and adaptive immunity have become very important areas of investigation for psychiatric, neurologic, and neurodevelopmental disorders, and neurodegeneration resulting from traumatic brain injury. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20–21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of central nervous system diseases.
  • Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders: Proceedings of a Workshop Released: March 10, 2017
    Despite the high prevalence and burden of nervous system disorders, development of new therapeutics lags behind other disease areas. Gaps in understanding the underlying pathophysiology, a dearth of biomarkers, and limitations in the capacity of animal models to predict drug efficacy for human brain disorders have contributed to a high rate of late stage failures in drug development and decreased investment in neuroscience research programs at pharmaceutical companies. On September 12-13, 2016, the National Academies of Sciences, Engineering, and Medicine’s Forum on Neuroscience and Nervous System Disorders hosted a public workshop to explore opportunities to accelerate drug development absent predictive animal models.
  • International Perspectives on Integrating Ethical, Legal, and Social Considerations into the Development of Non-Invasive Neuromodulation Devices: Proceedings of a Workshop—in Brief Released: January 09, 2017
    Emerging neurotechnologies—devices and techniques designed to collect information about the brain or affect its function—are becoming increasingly important due to scientific and technological advances and a persistent need to develop effective therapies to address the large global burden of neurological and psychiatric disease. The Organisation for Economic Co-operation and Development (OECD)—in collaboration with Arizona State University and the National Academies of Sciences, Engineering, and Medicine—held a workshop in Washington, DC, on Neurotechnology and Society: Strengthening Responsible Innovation in Brain Science.
  • Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop Released: November 18, 2016
    Califf was the keynote speaker at a workshop on multimodality therapies for brain disorders, convened by the National Academies of Sciences, Engineering, and Medicine’s Forum on Neuroscience and Nervous Systems Disorders. The workshop brought together key stakeholders to examine the general principles underlying multimodal therapies and to explore challenges, potential barriers, and opportunities for their development from multiple perspectives, including scientific, clinical, regulatory, and financial. These proceedings chronicle the presentations and discussions at the workshop.