Husseini K. Manji, M.D., is Global Head, Neuroscience at Johnson and Johnson Pharmaceutical Research and Development. He was previously Chief, Laboratory of Molecular Pathophysiology & Experimental Therapeutics, NIMH, and Director of the NIMH Mood and Anxiety Disorders Program, the largest program of its kind in the world. He is also a visiting professor in the Department of Psychiatry at Duke University. Dr. Manji received his B.S. (Biochemistry) and M.D. from the University of British Columbia. Following psychiatry residency training, he completed fellowship training in psychopharmacology at the NIMH and obtained extensive additional training in cellular and molecular biology at the NIDDK. The major focus of his ongoing research is the investigation of disease- and treatment-induced changes in gene and protein expression profiles that regulate synaptic and neural plasticity in mood disorders. His work has helped to conceptualize these illnesses as genetically-influenced disorders of synaptic and neural plasticity, and has led to the investigation of novel therapeutics for refractory mood disorders. Additionally, he has worked extensively on the development of diagnostic and treatment response biomarkers.
Dr. Manji is a previous recipient of numerous research awards, including the A. E. Bennett Award for Neuropsychiatric Research, the Ziskind-Somerfeld Award for Neuropsychiatric Research, the NARSAD Mood Disorders Prize (Falcone Prize), the Mogens Schou Distinguished Research Award, the American College of Neuropsychopharmacology (ACNP)’s Joel Elkes award for distinguished research, the Canadian Association of Professors in Psychiatry Award, the Henry and Page Laughlin Distinguished Teacher Award, the Brown University School of Medicine Distinguished Researcher Award, the DBSA Klerman Senior Distinguished Researcher Award, the NIMH award for excellence in clinical care and research, and the NIMH Director’s Career Research Award for significant scientific achievement. In addition to his research endeavors, Dr. Manji is also actively involved in medical and neuroscience education endeavors, and has served as a member of the National Board of Medical Examiners (NMBE) Behavioral Science Test Committee, the Howard Hughes Medical Institute Research Scholars Program Selection and Advisory Committee, and numerous national curriculum committees. He has developed and co-directs the NIH Foundation for the Advanced Education in the Sciences Graduate Course in the Neurobiology of Mental Illness, and has received both the NIMH Mentor of the year and NIMH Supervisor of the year awards. He has published extensively on the molecular and cellular neurobiology of severe mood disorders and their treatments, is editor of Neuropsychopharmacology Reviews: the next generation of progress, deputy editor of Biological Psychiatry, associate editor of the journal Bipolar Disorders, and sits on the editorial board of numerous journals. He is a Councilor of the ACNP, chairs the ACNP’s Task Force on New Medication Development, and is president of the Society of Biological Psychiatry.