Disruptive Innovation and the Transformation of the Drug Development and Translational Science Enterprise
This collaborative has sunset as of July 2016. This page will no longer be updated.
The Transformation and Disruptive Innovation: Envisioning the Drug Development and Translational Science Enterprise of the Future Action Collaborative is an ad hoc activity associated with the Forum on Drug Discovery, Development, and Translation (Forum) at the National Academies of Sciences, Engineering, and Medicine (the National Academies). Any products do not necessarily represent the views of any one organization, the Forum, or the National Academies and has not been subjected to the review procedures of, nor is it a report or product of, the National Academies.
Many argue that the current paradigm for drug discovery and development requires disruptive innovation to break out of a crisis in research and development (R&D) productivity. Evidence suggests that industries are almost always disrupted from the outside by new technologies they were slow to embrace, new business models they wrongly dismissed, or policy changes they thought they could keep at bay. The pharmaceutical industry offers many opportunities for disruption in each of these areas. The goal of the Disruptive Innovation and Transformation of the Drug Discovery and Development Enterprise action collaborative (Collaborative) was to identify and highlight potentially breakthrough ideas and visionary approaches to the “drug development and translational science enterprise of the future.” The effort addressed new technologies (e.g., biosensors, apps and telemetry, synthetic biology, new delivery technologies); new business models (e.g., crowdsourcing platforms, drug repurposing, virtual companies, clinical trials); and policy issues (e.g., pricing/reimbursement, patent law, data transparency). The effort included a data gathering phase and review phase involving the Forum membership, and culminated in the release of a Perspective.
Disruptive Innovation and Transformation of the Drug Discovery and Development Enterprise
Bernard H. Munos and John J. Orloff
National Academy of Medicine
July 10, 2016
Two Collaborative participants authored a Perspective, Disruptive Innovation and Transformation of the Drug Discovery and Development Enterprise, released by the National Academy of Medicine on July 20, 2016. The authors describe the process by which Collaborative participants engaged thought leaders and key stakeholders within the biomedical research ecosystem, soliciting diverse viewpoints to gain insight into their unique perspectives on the state of the pharmaceutical and biomedical research industries, what could or should change, how those changes might occur, and, generally, what the future might hold.