Activity

Identifying and Prioritizing New Preventive Vaccines for Development


Type: Consensus Study
Topics: Public Health
Board: Board on Population Health and Public Health Practice

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Activity Description

Project Scope

An ad hoc committee of the Institute of Medicine will develop an evidence-based approach and methodology for identifying and prioritizing the needs for developing new preventive vaccines of domestic and global importance. The committee will conduct its work in two phases.

PHASE I (Completed): Developing an Analytical Framework and Model for Prioritizing New Vaccines

Task 1: Review domestic and global research and development prioritization activities relevant to identifying new preventive vaccine targets.
Task 2: Develop an analytical framework and model for prioritizing vaccines of domestic and global importance. Engage stakeholders to inform the process of the model development and implementation.
Task 3: Test and validate the model using 2-3 predetermined vaccines, including at least one vaccine candidate of domestic importance and one of global importance.
Task 4: Prepare a report containing the analytical framework and model for evaluating and prioritizing vaccine targets along with recommendations as to how to use the model for reviewing the catalog of preventive vaccines every 2 to 3 years.

A report entitled "Ranking Vaccines: A Prioritization Framework (Phase I: Demonstration of Concept and a Software Blueprint)" was released on 10 May 2012.


PHASE II: Developing a Decision-Support Tool for Prioritizing New Vaccines

Task 1: Engage stakeholders and obtain feedback about the usefulness of the prototype model developed in phase I for prioritizing new preventive vaccines for development.
Task 2: Make modifications to the prototype model and test three additional pre-determined vaccine candidates of domestic and global importance.
Task 3: Prepare a report containing the enhanced model, test results, and recommendations for strategies toward developing a catalog of vaccine targets.

This study is funded by the National Vaccine Program Office at the U.S. Department of Health and Human Services. The start date for the Phase I was November 2010. The start date for Phase II is August 2012. The Phase II report is expected to be released in September 2013.

 

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